SCIENTIST, EDUCATOR, INNOVATOR
I am greatly interested in translational science, and have focused my career on advancing novel therapies from the laboratory bench. Former Assistant Professor of Medicine at Harvard Medical School, and a Scientific-Founder of Magenta Therapeutics, I am currently the Senior Director of Hematology and Immune Therapeutics at Moderna. Broad expertise in stem cell science, immunology, gene therapy, regenerative medicine, and hematology, with a track record of developing multiple therapeutic approaches now being explored in clinical trials.
SCIENTIST, EDUCATOR, INNOVATOR
I am greatly interested in translational science, and have focused my career on advancing novel therapies from the laboratory bench. Former Assistant Professor of Medicine at Harvard Medical School, and a Scientific-Founder of Magenta Therapeutics, I am currently the Senior Director of Hematology and Immune Therapeutics at Moderna. Broad expertise in stem cell science, immunology, gene therapy, regenerative medicine, and hematology, with a track record of developing multiple therapeutic approaches now being explored in clinical trials.
Moderna
Senior Director of Hematology and Immune Therapeutics
Mar 2021 – Present
Magenta Therapeutics
Scientific Co-founder
Nov 2016
Harvard Stem Cell Institute
Principal Faculty
Jun 2015 – Mar 2022
Harvard Medical School
Assistant Professor of Medicine
Jun 2015 – Mar 2022
Harvard University
Affiliate Faculty Member
Stem Cell and Regenerative Biology
Jun 2015 – Mar 2022
Harvard University
Postdoctoral Fellow
Jun 2011 – Jun 2015
City of West Lafayette
City Councilor
Oct 2009 – May 2011
City of West Lafayette
Police Commissioner
Mar 2006 – Oct 2009
[ EDUCATION ]
HARVARD UNIVERSITY
Post-Doctoral Fellowship,
Stem Cell Biology
2011 – 2015
Indiana University School of Medicine
Doctor of Philosophy (Ph.D.), Hematology
2006 – 2010
Indiana University–Purdue University Indianapolis
Master’s Degree, Biology
2005 – 2006
PURDUE UNIVERSITY
Bachelor’s Degree, Pharmaceutical Sciences
2001 – 2005
[ SKILLS ]
[ HONORS & AWARDS ]
American Society of Hematology Scholar Award
Issued by American Society of Hematology · Jul 2019
Research Rumble Champion
Issued by Mass General Brigham / Cambridge Science Festival · Apr 2017
Thomas T. Hoopes Prize Mentor Award
Issued by Harvard University · May 2016
Thomas T. Hoopes Prize Mentor Award
Issued by Harvard University · May 2013
Esther L. Kinsley Ph.D. Dissertation Award
Issued by Indiana University · May 2010
SELECT 15 OF 57
[ PUBLICATIONS ]
Hoggatt J, Mohammad KS, Singh P, Hoggatt AF, Chitteti BR, Speth JM, Hu P, Poteat BA, Stilger KN, Ferraro F, Silberstein L, Wong FK, Farag SS, Czader M, Milne GL, Breyer RM, Serezani CH, Scadden DT, Guise T, Srour EF, Pelus, LM. “Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2”. Nature 2013, Mar 21;495(7441):365-9.
Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour MK,Tate TA, Chan YY, Walck E, Wernig G, Shizuru JA, Winau F, Scadden DT, Rossi DJ. “Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation.” Nature Communications, 2019; Feb6;10(1):617-628.
Broxmeyer HE*, Hoggatt J*, O’Leary HA, Mantel C, Chitteti BR, Cooper S, Messina-Graham S, Hangoc G, Farag S, Rohrabaugh SL, Ou X, Speth JM, Pelus LM, Srour EF, Campbell TB. “CD26/Dipeptidylpeptidase IV Negatively Regulates Colony Stimulating Factor Activity and Stress Hematopoiesis”. Nature Medicine 2012, Dec;18(12):1786-9. *co-first authors
Hoggatt J*, Singh P, Tate TA, Chou BK, Datari SR, Fukuda S, Liu L, Kharchenko PV, Schajnovitz A, Baryawno N, Mercier FE, Boyer J, Gardner J, Morrow DM, Scadden DT, Pelus LM. “Rapid mobilization reveals a highly engraftable hematopoietic stem cell.” Cell, 2018; Jan11;172(1-2):191-204. *lead corresponding author
Menendez-Gonzalez JB and Hoggatt J. “Hematopoietic Stem Cell Mobilization: Current Collection Approaches, Stem Cell Heterogeneity, and a Proposed New Method for Stem Cell Transplant Conditioning.” Stem Cell Reviews and Reports, 2021 Dec;17(6):1939-1953.
Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. “Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic cell-specific internalizing immunotoxin.” Nature Biotechnology, 2016 Jul;34(7):738-745.
Hoggatt J, Singh P, Stilger KN, Plett PA, Sampson CH, Chua HL, Orschell CM, Pelus LM. “Recovery from hematopoietic injury by modulating prostaglandin E(2) signaling post-irradiation.” Blood Cells Molecule and Diseases 2013;50(3):147-53.
Hoggatt J*, Tate TA and Pelus LM*. “Hematopoietic Stem and Progenitor Cell Mobilization in Mice.” 3rd Edition Hematopoietic Stem Cell Protocols, Methods in Molecular Medicine, Humana Press, 2014;1185:43-64. *co-corresponding authors
Hoggatt J, Mohammad KS, Singh P, Pelus LM. “Prostaglandin E2 Enhances Long-term Repopulation but Does Not Permanently Alter Inherent Stem Cell Competitiveness.” Blood 2013;122(17):2997 – 3000.
Hoggatt J*+, Hoggatt AF*, Tate TA, Fortman J, Pelus LM+. “Bleeding the Laboratory Mouse: Not All Methods are Equal.” Experimental Hematology, 2016: Feb;44(2):132-137.
*co-first authors
Hoggatt J, Pelus LM. “Eicosanoid regulation of hematopoiesis and hematopoietic stem and progenitor trafficking.” Leukemia 2010;24(12):1993-2002.
Hoggatt J, Scadden DT. “The Stem Cell Niche: Tissue Physiology at a Single Cell Level.” Journal of Clinical Investigation 2012;122(9):3029-34.
Hoggatt J, Singh P, Sampath J, Pelus LM. “Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation”. Blood 2009;113(22):5444-55.
Hoggatt J, Kfoury Y and Scadden DT. “Hematopoietic Stem Cell Niche in Health and Disease.” Annual Review of Pathology, 2016;11:555-581.
Hoggatt J. “Gene Therapy for ‘Bubble Boy’ Disease.” Cell, 2016; Jul 14;166(2):263.
[ PATENTS ]
[ PRESS ]
Helping People in Need of a Stem Cell Transplant
Harvard stem cell research lead Jonathan Hoggatt joins Moderna as Director of Hematology
Moderna Hires Harvard Stem Cell Researcher Jonathan Hoggatt as Director of Hematology: What You Need to Know
What Defines a Stem Cell? Scientists Rethink the Answer | Quanta Magazine
Welcome to the Age of One-Shot Miracle Cures That Can Cost Millions
Five Things to Know About Bone Marrow and Stem Cell Harvest
Get your money back if pricey new gene therapy doesn't cure you
Gun Violence: A Public Health Crisis
